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FDA uses PROMIS® to Evaluate Fatigue in Patients Taking Jakafi for Myelofibrosis

An exploratory analysis of patients receiving Jakafi also showed improvement in fatigue-related symptoms (i.e., tiredness, exhaustion, mental tiredness, and lack of energy) and associated impacts on daily activities (i.e., activity limitations related to work, self-care, and exercise) as measured by the PROMIS Fatigue 7-item short form total score at Week 24. Patients who achieved a reduction of 4.5 points or more from baseline to Week 24 in the PROMIS Fatigue total score were considered to have achieved a fatigue response. Fatigue response was reported in 35% of patients in the Jakafi group versus 14% of the patients in the placebo group.

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PROMIS® (Patient-Reported Outcomes Measurement Information System) is a set of person-centered measures that evaluates and monitors physical, mental, and social health in adults and children. It can be used with the general population and with individuals living with chronic conditions.


  • Developed and validated with state-of-the-science methods to be psychometrically sound and to transform how life domains are measured
  • Designed to enhance communication between clinicians and patients in diverse research and clinical settings
  • Created to be relevant across all conditions for the assessment of symptoms and functions
  • Available in multiple formats and easily integrated into diverse data collection tools. Try the PROMIS CAT Demo>>
  • Translations available in Spanish and many other languages


HealthMeasures is the official information and distribution center for PROMIS, Neuro-QoL, NIH Toolbox®, and ASCQ-Me®, which were developed and evaluated with National Institutes of Health (NIH) funding. 

PROMIS, Patient-Reported Outcomes Measurement Information System, and the PROMIS logo are marks owned by the U. S. Department of Health and Human Services.